Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

Sparwasser, Tim; Koch, Eva-Sophie; Martin Vabulas, R.; Heeg, Klaus; B. Lipford, Grayson; W. Ellwart, Joachim; Wagner, Hermann

doi:10.1002/(sici)1521-4141(199806)28:06<2045::aid-immu2045>3.0.co;2-8

Public

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

Published in European Journal of Immunology • Jun 1, 1998

Authors:

Tim Sparwasser

Eva-Sophie Koch

R. Martin Vabulas

Abstract

Bacterial DNA and immunostimulatory (i.s.) synthetic CpG-oligodeoxynucleotides (ODN) act as adjuvants for Th1 responses and cytotoxic T cell responses to proteinaceous antigens. Dendritic cells (DC) can be referred to as "nature's adjuvant" since they display the unique capacity to sensitize naive T...

Subject

Biology

CpG Oligodeoxynucleotide

CD40

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