Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression

Liu, Huanliang; Chao, David; E. Nakayama, Emi; Taguchi, H; Goto, Mieko; Xin, Xiaomi; Takamatsu, Junki; Saito, Hidehiko; Ishikawa, Yoshihide; Akaza, Tatsuya; Juji, Takeo; Takebe, Yutaka; Ohishi, T.; Fukutake, Katsuyuki; Maruyama, Yoshikazu; Yashiki, Shinji; Sonoda, Shunro; Nakamura, Tetsuya; Nagai, Yoshiyuki; Iwamoto, Aikichi; Shioda, Tatsuo

doi:10.1073/pnas.96.8.4581

Public

Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression

Published in Proceedings of the National Academy of Sciences • Apr 13, 1999

Authors:

Huanliang Liu

David Chao

Emi E. Nakayama

Abstract

RANTES (regulated on activation normal T cell expressed and secreted) is one of the natural ligands for the chemokine receptor CCR5 and potently suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Previous studies showed that peripheral blood mononuclear cells...

Subject

Chemokine

Biology

Peripheral blood mononuclear cell

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