Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

Foretz, Marc; Hébrard, Sophie; Leclerc, Jocelyne; Zarrinpashneh, Elham; Soty, Maud; Mithieux, Gilles; Sakamoto, Kei; Andréelli, Fabrizio; Viollet, Benoı̂t

doi:10.1172/jci40671

Public

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

Published in Journal of Clinical Investigation • Jun 24, 2010

Authors:

Marc Foretz

Sophie Hébrard

Jocelyne Leclerc

Abstract

Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the action of metformin on hepatic gluconeogenesis. However, the molecular mechanism by which this pathway operates had rema...

Subject

Metformin

Gluconeogenesis

AMPK

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