A Novel Organometallic Aqua Complex of Technetium for the Labeling of Biomolecules: Synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4]- in Aqueous Solution and Its Reaction with a Bifunctional Ligand

We present herein the first synthesis of the water and air stable organometallic aqua complex [99mTc(OH2)3(CO)3]+ directly from [99mTcO4]- in saline under 1 atm of CO. Subsequent substitution of the labile water ligands by a bifunctional ligand attachable to biomolecules enables the introduction of ... View More