Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability

D. Markowitz, Sanford; Wang, Jing; L. Myeroff, Lois; Parsons, Ramon; Sun, Lu‐Zhe; Lutterbaugh, James; S. Fan, Robert; Zborowska, Elizabeth; W. Kinzler, Kenneth; Vogelstein, Bert; G. Brattain, Michael; K. V. Willson, James

doi:10.1126/science.7761852

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Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability

Published in Science • Jun 2, 1995

Authors:

Sanford D. Markowitz

Jing Wang

Lois L. Myeroff

Abstract

Transforming growth factor-beta (TGF-beta) is a potent inhibitor of epithelial cell growth. Human colon cancer cell lines with high rates of microsatellite instability were found to harbor mutations in the type II TGF-beta receptor (RII) gene. Eight such examples, due to three different mutations, w...

Subject

Microsatellite instability

Transforming growth factor

Receptor

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