Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data

W. Bigham, Abigail; Bauchet, Marc; Pinto, Dalila; Mao, Xianyun; M. Akey, Joshua; Mei, Rui; W. Scherer, Stephen; G. Julian, Colleen; J. Wilson, Megan; López Herráez, David; D. Brutsaert, Tom; J. Parra, Esteban; G. Moore, Lorna; D. Shriver, Mark

doi:10.1371/journal.pgen.1001116

Public

Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data

Published in PLoS Genetics • Sep 9, 2010

Authors:

Abigail W. Bigham

Marc Bauchet

Dalila Pinto

Abstract

High-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric pressure) exerts severe physiological stress on the human body. Two high-altitude regions where humans have lived for millennia are the Andean Altiplano and the Tibetan Plateau. Populations living in these regions exh...

Subject

Biology

Natural selection

Gene

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