A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness

O’Connell, Jared; Gurdasani, Deepti; Delaneau, Olivier; Pirastu, Nicola; Ulivi, Sheila; Cocca, Massimiliano; Traglia, Michela; Huang, Jie; E. Huffman, Jennifer; Rudan, Igor; McQuillan, Ruth; M. Fraser, Ross; Campbell, Harry; Polašek, Ozren; Asiki, Gershim; Ekoru, Kenneth; Hayward, Caroline; F. Wright, Alan; Vitart, Véronique; Navarro, Pau; Zagury, Jean-François; F. Wilson, James; Toniolo, Daniela; Gasparini, Paolo; Soranzo, Nicole; S. Sandhu, Manjinder; Marchini, Jonathan

doi:10.1371/journal.pgen.1004234

Public

A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness

Published in PLoS Genetics • Apr 17, 2014

Authors:

Jared O’Connell

Deepti Gurdasani

Olivier Delaneau

Abstract

Many existing cohorts contain a range of relatedness between genotyped individuals, either by design or by chance. Haplotype estimation in such cohorts is a central step in many downstream analyses. Using genotypes from six cohorts from isolated populations and two cohorts from non-isolated populati...

Subject

Haplotype

Biology

Genotyping

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