SET Domain-containing Protein, G9a, Is a Novel Lysine-preferring Mammalian Histone Methyltransferase with Hyperactivity and Specific Selectivity to Lysines 9 and 27 of Histone H3

Tachibana, Makoto; Sugimoto, Kenji; Fukushima, Tatsunobu; Shinkai, Yoichi

doi:10.1074/jbc.m101914200

Public

SET Domain-containing Protein, G9a, Is a Novel Lysine-preferring Mammalian Histone Methyltransferase with Hyperactivity and Specific Selectivity to Lysines 9 and 27 of Histone H3

Published in Journal of Biological Chemistry • Jan 1, 2001

Authors:

Makoto Tachibana

Kenji Sugimoto

Tatsunobu Fukushima

Abstract

The covalent modification of histone tails has regulatory roles in various nuclear processes, such as control of transcription and mitotic chromosome condensation. Among the different groups of enzymes known to catalyze the covalent modification, the most recent additions are the histone methyltrans...

Subject

Histone H3

Histone methyltransferase

Lysine

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