Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

Yu, Yingying; Xiao, C-H; Tan, L-D; Wang, Q-S; Li, Xiaoqing; Feng, Y-M

doi:10.1038/bjc.2013.768

Public

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

Published in British Journal of Cancer • Dec 12, 2013

Authors:

Yingying Yu

C-H Xiao

L-D Tan

Abstract

BACKGROUND: Cancer-associated fibroblasts (CAFs) activated by tumour cells are the predominant type of stromal cells in breast cancer tissue. The reciprocal effect of CAFs on breast cancer cells and the underlying molecular mechanisms are not fully characterised. METHODS: Stromal fibroblasts were is...

Subject

Paracrine signalling

Cancer research

Breast cancer

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