Identification of Amino Acids in HA and PB2 Critical for the Transmission of H5N1 Avian Influenza Viruses in a Mammalian Host

Gao, Yuwei; Zhang, Ying; Shinya, Kyoko; Deng, Guohua; Jiang, Yongping; Li, Zejun; Guan, Yuntao; Tian, Guobin; Li, Yanbing; Shi, Jianzhong; Liu, Liling; Zeng, Xianying; Bu, Zhigao; Xia, Xianzhu; Kawaoka, Yoshihiro; Chen, Hualan

doi:10.1371/journal.ppat.1000709

Public

Identification of Amino Acids in HA and PB2 Critical for the Transmission of H5N1 Avian Influenza Viruses in a Mammalian Host

Published in PLoS Pathogens • Dec 23, 2009

Authors:

Yuwei Gao

Ying Zhang

Kyoko Shinya

Abstract

Since 2003, H5N1 influenza viruses have caused over 400 known cases of human infection with a mortality rate greater than 60%. Most of these cases resulted from direct contact with virus-contaminated poultry or poultry products. Although only limited human-to-human transmission has been reported to ...

Subject

Influenza A virus subtype H5N1

Virology

Biology

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