NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells

R. Mantegazza, Adriana; Savina, Ariel; Vermeulen, Mónica; Pérez, Laura; Geffner, Jorge; Hermine, Olivier; D. Rosenzweig, Sergio; Faure, Florence; Amigorena, Sebastián

doi:10.1182/blood-2008-01-134791

Public

NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells

Published in Blood • Aug 6, 2008

Authors:

Adriana R. Mantegazza

Ariel Savina

Mónica Vermeulen

Abstract

The phagocyte NADPH oxidase (NOX2) is critical for the bactericidal activity of phagocytic cells and plays a major role in innate immunity. We showed recently that NOX2 activity in mouse dendritic cells (DCs) prevents acidification of phagosomes, promoting antigen cross-presentation. In order to inv...

Subject

Phagosome

Cross-presentation

NADPH oxidase

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