Reference Genes for Real-Time PCR Quantification of MicroRNAs and Messenger RNAs in Rat Models of Hepatotoxicity

Noelia Lardizábal, María; Lía Nocito, Ana; Maris Daniele, Stella; Ornella, Leonardo; F. Palatnik, Javier; M. Veggi, Luis

doi:10.1371/journal.pone.0036323

Public

Reference Genes for Real-Time PCR Quantification of MicroRNAs and Messenger RNAs in Rat Models of Hepatotoxicity

Published in PLoS ONE • May 1, 2012

Authors:

María Noelia Lardizábal

Ana Lía Nocito

Stella Maris Daniele

Abstract

Hepatotoxicity is associated with major changes in liver gene expression induced by xenobiotic exposure. Understanding the underlying mechanisms is critical for its clinical diagnosis and treatment. MicroRNAs are key regulators of gene expression that control mRNA stability and translation, during n...

Subject

Reference genes

Gene expression

microRNA

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