The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Xu, Xun; Nagarajan, Harish; E. Lewis, Nathan; Pan, Shengkai; Cai, Zhiming; Liu, Xin; Chen, Wenbin; Xie, Min; Wang, Wenliang; Hammond, Stephanie; Rørdam Andersen, Mikael; Neff, Norma; Passarelli, Benedetto; Koh, Winston; Christina Fan, H.; Wang, Jianbin; Wang, Jianbin; Gui, Yaoting; H. Lee, Kelvin; J Betenbaugh, Michael; R. Quake, Stephen; Famili, Iman; Ø. Palsson, Bernhard; Wang, Jun; Wang, Jun

doi:10.1038/nbt.1932

Public

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

Published in Nature Biotechnology • Jul 31, 2011

Authors:

Xun Xu

Harish Nagarajan

Nathan E. Lewis

Abstract

Since 1987, immortalized cells from the ovary of a Chinese hamster have been the workhorse for producing recombinant therapeutics, including monoclonal antibodies, blood factors, hormones, growth factors and enzymes. Xu et al. provide the genome sequence of the ancestral CHO-K1 cell line, which shou...

Subject

Chinese hamster ovary cell

Biology

Gene

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