A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

K Manning, Alisa; Hivert, Marie‐France; A. Scott, Robert; Grimsby, Jonna; Bouatia‐Naji, Nabila; Chen, Han; Rybin, Denis; Liu, Ching‐Ti; F. Bielak, Lawrence; Prokopenko, Inga; Amin, Najaf; R. Barnes, Daniel; Cadby, Gemma; Hottenga, Jouke‐Jan; Ingelsson, Erik; Jackson, Anne; Johnson, Toby; Kanoni, Stavroula; Ladenvall, Claes; Lagou, Vasiliki; Lahti, Jari; Lecœur, Cécile; Liu, Ching‐Ti; G. Martin, Nicholas; E. Montasser, May; Navarro, Pau; R. B. Perry, John; J. Rasmussen‐Torvik, Laura; Salo, Perttu; Sattar, Naveed; Shungin, Dmitry; J. Strawbridge, Rona; Tanaka, Toshiko; M. van Duijn, Cornelia; An, Ping; de Andrade, Mariza; S. Andrews, Jeanette; Aspelund, Thor; Atalay, Mustafa; S. Aulchenko, Yurii; Balkau, Beverley; Bandinelli, Stefania; Beckmann, J.; Beilby, John; Bellis, Claire; N. Bergman, Richard; Blangero, John; Boban, Mladen; Boehnke, Michael; Boerwinkle, Eric; L. Bonnycastle, Lori; I. Boomsma, Dorret; B. Borecki, Ingrid; Böttcher, Yvonne; Bouchard, Claude; J. Brunner, Eric; Budimir Mršić, Danijela; Campbell, Harry; D. Carlson, Olga; S. Chines, Peter; Clarke, Robert; S. Collins, Francis; Corbatón Anchuelo, Arturo; Couper, David; dé Fairé, Ulf; Dedoussis, George; Deloukas, Panos; Dimitriou, Maria; M. Egan, Josephine; Eiríksdóttir, Guðný; R. Erdos, Michael; G. Eriksson, Johan; Eury, Elodie; Ferrucci, Luigi; Ford, Ian; G. Forouhi, Nita; S. Fox, Caroline; Grazia Franzosi, Maria; W. Franks, Paul; M Frayling, Timothy; Froguel, Philippe; Galan, Pilar; J. C. de Geus, Eco; Gigante, Bruna; L. Glazer, Nicole; Goel, Anuj; Groop, Leif; Guðnason, Vilmundur; Hallmans, Göran; Hamsten, Anders; Hansson, Ola; B. Harris, Tamara; Hayward, Caroline; Heath, Simon; Herçberg, Serge; A. Hicks, Andrew; D. Hingorani, Aroon; Hofman, Albert; Hui, Jennie; Hung, Joseph; Järvelin, Marjo‐Riitta; A. Jhun, Min; Johnson, P.; Wouter Jukema, J.; Jula, Antti; Linda Kao, W.H.; Kaprio, Jaakko; L. R. Kardia, Sharon; Keinänen‐Kiukaanniemi, Sirkka; Kivimäki, Mika; Kolčić, Ivana; Kovács, Péter; Kumari, Meena; Kuusisto, Johanna; Ohm Kyvik, Kirsten; Laakso, Markku; A. Lakka, Timo; Lannfelt, Lars; Lathrop, G.M.; J. Launer, Lenore; Leander, Karin; Li, Guo; Lind, Lars; Lindström, Jaana; Lobbens, Stéphane; J. F. Loos, Ruth; Luan, Jian'an; Lyssenko, V.; Mägi, Reedik; K. E. Magnusson, Patrik; Marmot, Michael; Meneton, Pierre; L. Mohlke, Karen; Mooser, Vincent; A. Morken, Mario; Miljkovic, Iva; Narisu, Narisu; O’Connell, Jeff; K. Ong, Ken; A Oostra, Ben; J. Palmer, Lyle; Palotie, Aarno; S. Pankow, James; F. Peden, John; L. Pedersen, Nancy; Pehlić, Marina; Peltonen, Leena; W.J.H. Penninx, Brenda; Peričić, Marijana; Perola, Markus; Përusse, Louis; A. Peyser, Patricia; Polašek, Ozren; P. Pramstaller, Peter; A. Province, Michael; Räikkönen, Katri; Rauramaa, Rainer; Rehnberg, Emil; Rice, Kenneth; I. Rotter, Jerome; Rudan, Igor; Ruokonen, A; Saaristo, Timo; Sabater‐Lleal, Maria; Salomaa, Veikko; B. Savage, David; Saxena, Richa; Schwarz, Peter; Seedorf, Udo; Sennblad, Bengt; Serrano‐Ríos, Manuel; R. Shuldiner, Alan; J.G. Sijbrands, Eric; S. Siscovick, David; H. Smit, Johannes; S. Small, Kerrin; L. Smith, Nicholas; V. Smith, Albert; Stančáková, Alena; Stirrups, Kathleen; Stümvoll, Michael; V. Sun, Yan; J. Swift, Amy; Tönjes, Anke; Tuomilehto, J.; Trompet, Stella; G. Uitterlinden, André; Uusitupa, Matti; Vikström, Max; Vitart, Véronique; Vohl, Marie‐Claude; F. Voight, Benjamin; Vollenweider, Péter; Waeber, Gérard; Waterworth, Dawn; Watkins, Hugh; Wheeler, Eleanor; Widén, Elisabeth; H Wild, Sarah; M. Willems, Sara; Willemsen, Gonneke; F. Wilson, James; C.M. Witteman, Jacqueline; F. Wright, Alan; Yaghootkar, Hanieh; Zélénika, Diana; Zemunik, Tatijana; Zgaga, Lina; J. Wareham, Nicholas; I. McCarthy, Mark; Barroso, Inês; M. Watanabe, Richard; C. Florez, José; Dupuis, Josée; B. Meigs, James; Langenberg, Claudia

doi:10.1038/ng.2274

Public

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Published in Nature Genetics • May 13, 2012

Authors:

Alisa K Manning

Marie‐France Hivert

Robert A. Scott

Abstract

Claudia Langenberg, James Meigs and colleagues apply a joint meta-analysis approach that accounts for differences in body mass index to identify variants associated with glycemic traits. They report six new loci associated with fasting insulin levels and provide insights into the genetic basis of in...

Subject

Biology

Insulin resistance

Body mass index

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