Mucoid Pseudomonas aeruginosa , TNF-α, and IL-1 β, but Not IL-6, Induce Human β-Defensin-2 in Respiratory Epithelia

Cultured lung epithelial cells release antibacterial activity upon contact with Pseudomonas aeruginosa (PA), which is impaired in cystic fibrosis (CF). In order to identify the factors responsible for killing PA by a biochemical approach, we purified antimicrobial activity from supernatants of the A... View More