Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells

Malignant breast tissue contains a rare population of multi-potent cells with the capacity to self-renew; these cells are known as cancer stem-like cells (CSCs) or tumor-initiating cells. Primitive mammary CSCs/progenitor cells can be propagated in culture as floating spherical colonies termed 'mamm... View More