Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

Kornau, Hans‐Christian; T. Schenker, Leslie; B. Kennedy, Mary; H. Seeburg, P.

doi:10.1126/science.7569905

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Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

Published in Science • Sep 22, 1995

Authors:

Hans‐Christian Kornau

Leslie T. Schenker

Mary B. Kennedy

Abstract

The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95. The second PD...

Subject

Postsynaptic density

PDZ domain

NMDA receptor

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