Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

G. Estévez, Álvaro; Radí, Rafael; Barbeito, Luis; T. Shin, Jordan; A. Thompson, John; S. Beckman, Joseph

doi:10.1046/j.1471-4159.1995.65041543.x

Public

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

Published in Journal of Neurochemistry • Oct 1, 1995

Authors:

Álvaro G. Estévez

Rafael Radí

Luis Barbeito

Abstract

Peroxynitrite is a powerful oxidant formed by the near-diffusion-limited reaction of nitric oxide with superoxide. Large doses of peroxynitrite (> 2 mM) resulted in rapid cell swelling and necrosis of undifferentiated PC12 cells. However, brief exposure to lower concentrations of peroxynitrite (EC50...

Subject

Peroxynitrite

Aurintricarboxylic acid

Apoptosis

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