Peroxynitrite-induced cytotoxicity in PC12 cells: evidence for an apoptotic mechanism differentially modulated by neurotrophic factors.

AG, Estévez; R, Radi; L, Barbeito; JT, Shin; JA, Thompson; JS, Beckman

doi:10.1046/j.1471-4159.1995.65041543.x

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Peroxynitrite-induced cytotoxicity in PC12 cells: evidence for an apoptotic mechanism differentially modulated by neurotrophic factors.

Shared by NobleBlocks on Oct 1, 1995 • 12:00 AM UTC

Authors:

Estévez AG

Radi R

Barbeito L

Abstract

Peroxynitrite is a powerful oxidant formed by the near-diffusion-limited reaction of nitric oxide with superoxide. Large doses of peroxynitrite (> 2 mM) resulted in rapid cell swelling and necrosis of undifferentiated PC12 cells. However, brief exposure to lower concentrations of peroxynitrite (EC50...

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