Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.

Fielder, A.H.L.; Walport, Mark; R. Batchelor, J.; I. Rynes, Richard; M. Black, C.; Anthony Dodi, I.; R. V. Hughes, G.

doi:10.1136/bmj.286.6363.425

Public

Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.

Published in BMJ • Feb 5, 1983

Authors:

A.H.L. Fielder

Mark Walport

J. R. Batchelor

Abstract

The families of 29 patients with systemic lupus erythematosus and 42 normal subjects were studied to determine the inheritance of the HLA-A, B, C, and DR antigens and also the complement polymorphisms for C2, C4A, C4B, and Bf, which are encoded in the same region of the sixth chromosome. Null (silen...

Subject

C4A

Null allele

Allele

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