Baclofen decreases acid and non‐acid post‐prandial gastro‐oesophageal reflux measured by combined multichannel intraluminal impedance and pH

F. Vela, Marcelo; Țuțuian, Radu; O. Katz, Philip; O. Castell, D.

doi:10.1046/j.1365-2036.2003.01394.x

Public

Baclofen decreases acid and non‐acid post‐prandial gastro‐oesophageal reflux measured by combined multichannel intraluminal impedance and pH

Published in Alimentary Pharmacology & Therapeutics • Jan 1, 2003

Authors:

Marcelo F. Vela

Radu Țuțuian

Philip O. Katz

Abstract

BACKGROUND: Omeprazole controls acid but not non-acid reflux. The GABA B agonist baclofen decreases acid reflux through the inhibition of transient lower oesophageal sphincter relaxations (TLESRs) and should similarly decrease non-acid reflux. Using combined multichannel intraluminal impedance and p...

Subject

Reflux

Heartburn

Baclofen

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