Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of β‐oxidation

Larigauderie, Guilhem; Cuaz‐Pérolin, Clarisse; Ben Younes, Aména; Furman, Christophe; Lasselin, C.; Copin, Corinne; Jaye, Michael; Fruchart, Jean‐Charles; Rouis, Mustapha

doi:10.1111/j.1742-4658.2006.05357.x

Public

Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of β‐oxidation

Published in FEBS Journal • Jul 17, 2006

Authors:

Guilhem Larigauderie

Clarisse Cuaz‐Pérolin

Aména Ben Younes

Abstract

Lipid accumulation alters macrophage biology and contributes to lipid retention within the vessel wall. In this study, we investigated the role of adipophilin on triglyceride accumulation and lipid-droplet formation in THP-1-derived macrophages (THP-1 macrophages). In the presence of acetylated low-...

Subject

Triglyceride

Lipid droplet

Foam cell

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