Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

O. Martínez, Fernando; Helming, Laura; Milde, Ronny; Varin, Audrey; N. Melgert, Barbro; Draijer, Christina; Thomas, Benjamin; Fabbri, Marco; Crawshaw, Anjali; Ho, Ling‐Pei; H.T. ten Hacken, Nick; Cobos Jiménez, Viviana; A. Kootstra, Neeltje; Hamann, Jörg; R. Greaves, David; Locati, Massimo; Mantovani, Alberto; Gordon, Siamon

doi:10.1182/blood-2012-06-436212

Public

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

Published in Blood • Jan 5, 2013

Authors:

Fernando O. Martínez

Laura Helming

Ronny Milde

Abstract

The molecular repertoire of macrophages in health and disease can provide novel biomarkers for diagnosis, prognosis, and treatment. Th2-IL-4–activated macrophages (M2) have been associated with important diseases in mice, yet no specific markers are available for their detection in human tissues. Al...

Subject

Biology

Immunology

Molecular biology

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