Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

Nakamura, Seiji; Takamura, Toshinari; Nagata, Naoto; Takayama, Hiroaki; Misu, Hirofumi; Noda, Hiroyo; Nabemoto, Satoko; Kurita, Seiichiro; Ota, Tsuguhito; Ando, Hitoshi; Miyamoto, Ken‐ichi; Kaneko, Shuichi

doi:10.1074/jbc.m901488200

Public

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

Published in Journal of Biological Chemistry • Mar 31, 2009

Authors:

Seiji Nakamura

Toshinari Takamura

Naoto Nagata

Abstract

Visceral adiposity in obesity causes excessive free fatty acid (FFA) flux into the liver via the portal vein and may cause fatty liver disease and hepatic insulin resistance. However, because animal models of insulin resistance induced by lipid infusion or a high fat diet are complex and may be acco...

Subject

Insulin resistance

Internal medicine

Endocrinology

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