A tutorial on sensitivity analyses in clinical trials: the what, why, when and how

Thabane, Lehana; Mbuagbaw, Lawrence; Zhang, Shiyuan; Samaan, Zainab; Marcucci, Maura; Ye, Chenglin; Thabane, Marroon; Giangregorio, Lora; B. Dennis, Brittany; Daisy Kosa, Sarah; Borg Debono, Victoria; Dillenburg, Rejane; Fruci, Vincent; Bawor, Monica; Lee, Juneyoung; A. Wells, George; H. Goldsmith, Charles

doi:10.1186/1471-2288-13-92

Public

A tutorial on sensitivity analyses in clinical trials: the what, why, when and how

Published in BMC Medical Research Methodology • Jul 16, 2013

Authors:

Lehana Thabane

Lawrence Mbuagbaw

Shiyuan Zhang

Abstract

BACKGROUND: Sensitivity analyses play a crucial role in assessing the robustness of the findings or conclusions based on primary analyses of data in clinical trials. They are a critical way to assess the impact, effect or influence of key assumptions or variations--such as different methods of analy...

Subject

Sensitivity (control systems)

Clinical trial

Missing data

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