Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients

Rotger, Margalida; Colombo, Sara; Furrer, Hansjakob; Bleiber, Gabriela; Buclin, Thierry; L. Lee, Belle; Keiser, Olivia; Biollaz, Jérôme; A. Décosterd, Laurent; Telenti, Amalio

doi:10.1097/01213011-200501000-00001

Public

Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients

Published in Pharmacogenetics and Genomics • Jan 1, 2005

Authors:

Margalida Rotger

Sara Colombo

Hansjakob Furrer

Abstract

BACKGROUND: Efavirenz (EFV) and nevirapine (NVP) are metabolized by cytochrome P450 2B6 (CYP2B6). Allele 516 G>T (Gln172His) is associated with diminished activity of this isoenzyme, and may lead to differences in drug exposure. METHODS: We evaluated this allele as a pharmacogenetic marker of EFV an...

Subject

Efavirenz

CYP2B6

Nevirapine

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!