Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

Marrakchi, Slaheddine; Guigue, Philippe; R. Renshaw, Blair; Puel, Anne; Pei, Xue-Yuan; Fraïtag, Sylvie; Zribi, Jihen; Bal, Élodie; Cluzeau, Céline; Chrabieh, Maya; E. Towne, Jennifer; Douangpanya, Jason; Pons, Christian; Mansour, Sourour; Serre, Valérie; Makni, H.; Mahfoudh, Nadia; Fakhfakh, Faiza; Bodemer, Christine; Feingold, Josué; Hadj‐Rabia, S.; Fãvre, Michel; Génin, Emmanuelle; Sahbatou, Mourad; Münnich, Arnold; Casanova, Jean‐Laurent; E. Sims, John; Turki, H.; Bachelez, H.; Smahi, Asma

doi:10.1056/nejmoa1013068

Public

Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

Published in New England Journal of Medicine • Aug 17, 2011

Authors:

Slaheddine Marrakchi

Philippe Guigue

Blair R. Renshaw

Abstract

BACKGROUND: Generalized pustular psoriasis is a life-threatening disease of unknown cause. It is characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein, which may be associate...

Subject

Generalized pustular psoriasis

Medicine

Interleukin

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