Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity.

C, Volbracht; Beek J, van; C, Zhu; K, Blomgren; M, Leist

doi:10.1111/j.1460-9568.2006.04787.x

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Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity.

Shared by NobleBlocks on May 1, 2006 • 12:00 AM UTC

Authors:

Volbracht C

van Beek J

Zhu C

Abstract

The pathogenesis of stroke, trauma and chronic degenerative diseases, such as Alzheimer's disease (AD), has been linked to excitotoxic processes due to inappropriate stimulation of the N-methyl-D-aspartate receptor (NMDA-R). Attempts to use potent competitive NMDA-R antagonists as neuroprotectants h...

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