Early Bactericidal Activity and Pharmacokinetics of PA-824 in Smear-Positive Tuberculosis Patients

H. Diacon, Andreas; Dawson, Rodney; Hanekom, M.; Narunsky, Kim; J. Maritz, Stefan; Venter, Amour; R. Donald, Peter; van Niekerk, Christo; Whitney, Karl; Rouse, D.J.; Laurenzi, Martino; M. Ginsberg, Ann; Spigelman, Melvin

doi:10.1128/aac.01354-09

Public

Early Bactericidal Activity and Pharmacokinetics of PA-824 in Smear-Positive Tuberculosis Patients

Published in Antimicrobial Agents and Chemotherapy • May 25, 2010

Authors:

Andreas H. Diacon

Rodney Dawson

M. Hanekom

Abstract

PA-824 is a novel nitroimidazo-oxazine being evaluated for its potential to improve tuberculosis (TB) therapy. This randomized study evaluated safety, tolerability, pharmacokinetics, and extended early bactericidal activity of PA-824 in drug-sensitive, sputum smear-positive, adult pulmonary tubercul...

Subject

Pharmacokinetics

Tuberculosis

Medicine

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!