MGMT promoter methylation and field defect in sporadic colorectal cancer.

L, Shen; Y, Kondo; GL, Rosner; L, Xiao; NS, Hernandez; J, Vilaythong; PS, Houlihan; RS, Krouse; AR, Prasad; JG, Einspahr; J, Buckmeier; DS, Alberts; SR, Hamilton; JP, Issa

doi:10.1093/jnci/dji275

Public

MGMT promoter methylation and field defect in sporadic colorectal cancer.

Shared by NobleBlocks on Sep 1, 2005 • 12:00 AM UTC

Authors:

Shen L

Kondo Y

Rosner GL

Abstract

Background Sporadic colorectal cancers often arise from a region of cells characterized by a "field defect" that has not been well defined molecularly. DNA methylation has been proposed as a candidate mediator of this field defect. The DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is...

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