MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer

Shen, Lanlan; Kondo, Yutaka; L. Rosner, Gary; Xiao, Lianchun; Hernandez, Natalie; N. Vilaythong, Jill; Houlihan, Patrick; S. Krouse, Robert; Prasad, Anil; G. Einspahr, Janine; A. Buckmeier, Julie; S. Alberts, David; R. Hamilton, Stanley; J. Issa, Jean‐Pierre

doi:10.1093/jnci/dji275

Public

MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer

Published in JNCI Journal of the National Cancer Institute • Sep 20, 2005

Authors:

Lanlan Shen

Yutaka Kondo

Gary L. Rosner

Abstract

BACKGROUND: Sporadic colorectal cancers often arise from a region of cells characterized by a "field defect" that has not been well defined molecularly. DNA methylation has been proposed as a candidate mediator of this field defect. The DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) i...

Subject

Colorectal cancer

Methylation

Field (mathematics)

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