Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype.

Asunción García-González, M; Quintero, Enrique; Bujanda, Luis; Nicolás, David; Benito, Rafael; Strunk, Mark; Santolaria, Santos; Sopeña, Federico; Badía, María; Hijona, Elizabeth; Angeles Pérez-Aísa, M; M Méndez-Sánchez, Isabel; Thomson, Concha; Carrera, Patricia; Piazuelo, Elena; Jiménez, Pilar; Espinel, Jesús; Campo, Rafael; Manzano, Marisa; Geijo, Fernando; Pellisé, Maria; González-Huix, Ferrán; Espinós, Jorge; Titó, Llusia; Zaballa, Manuel; Pazo, Roberto; Lanas, Angel

doi:10.1093/mutage/ges049

Public

Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype.

Published in Mutagenesis • Nov 1, 2012

NobleIDark:/48914/w1/20260526/DF3420C3Record on NobleID

Authors:

M Asunción García-González

,

Enrique Quintero

,

Luis Bujanda

Abstract

Human glutathione S-transferases (GSTs) are phase II metabolizing enzymes that play a key role in protecting against cancer by detoxifying numerous potentially cytotoxic/genotoxic compounds. The genes encoding the human GST isoenzymes GSTM(mu)1, GSTT(theta)1 and GSTP(pi)1 harbour polymorphisms, whic...

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