An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss

M. Sicari, Brian; Peter Rubin, J.; L. Dearth, Christopher; T. Wolf, Matthew; Ambrosio, Fabrisia; L. Boninger, Michael; J. Turner, Neill; J. Weber, Douglas; W. Simpson, Tyler; Wyse, Aaron; H.P. Brown, Elke; L. Dziki, Jenna; E. Fisher, Lee; A. Brown, Spencer; F. Badylak, Stephen

doi:10.1126/scitranslmed.3008085

Public

An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss

Published in Science Translational Medicine • Apr 30, 2014

Authors:

Brian M. Sicari

J. Peter Rubin

Christopher L. Dearth

Abstract

Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffo...

Subject

Extracellular matrix

Skeletal muscle

Scaffold

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