High prevalence of triazole resistance in Aspergillus fumigatus, especially mediated by TR/L98H, in a French cohort of patients with cystic fibrosis

Morio, Florent; Ghislain Aubin, Guillaume; Danner‐Boucher, Isabelle; Haloun, A.; Sacchetto, Émilie; Garcia‐Hermoso, Dea; Bretagne, Stéphane; Miègeville, M.; Le Pape, Patrice

doi:10.1093/jac/dks160

Public

High prevalence of triazole resistance in Aspergillus fumigatus, especially mediated by TR/L98H, in a French cohort of patients with cystic fibrosis

Published in Journal of Antimicrobial Chemotherapy • May 11, 2012

Authors:

Florent Morio

Guillaume Ghislain Aubin

Isabelle Danner‐Boucher

Abstract

OBJECTIVES: Triazole resistance in Aspergillus fumigatus due to a single azole resistance mechanism (TR/L98H) is increasingly reported in European countries. Data from patients with cystic fibrosis (CF) are limited. Our study aimed to investigate the prevalence and molecular mechanisms of azole resi...

Subject

Itraconazole

Aspergillus fumigatus

Posaconazole

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