Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.

AF, Dessein; L, Stechly; N, Jonckheere; P, Dumont; D, Monté; E, Leteurtre; S, Truant; FR, Pruvot; M, Figeac; M, Hebbar; CH, Lecellier; T, Lesuffleur; R, Dessein; G, Grard; MJ, Dejonghe; Launoit Y, de; Y, Furuichi; G, Prévost; N, Porchet; C, Gespach; G, Huet

doi:10.1158/0008-5472.can-09-3828

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Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.

Shared by NobleBlocks on May 11, 2010 • 12:00 AM UTC

Authors:

Dessein AF

Stechly L

Jonckheere N

Abstract

Metastasis and drug resistance are major problems in cancer chemotherapy. The purpose of this work was to analyze the molecular mechanisms underlying the invasive potential of drug-resistant colon carcinoma cells. Cellular models included the parental HT-29 cell line and its drug-resistant derivativ...

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