Alteration of the microRNA network during the progression of Alzheimer's disease

Lau, Pierre; Bossers, Koen; Janky, Rekin’s; Salta, Evgenia; Sala Frigerio, Carlo; Barbash, Shahar; Rothman, Roy; Sierksma, Annerieke; Thathiah, Amantha; Greenberg, David; S. Papadopoulou, Aikaterini; Achsel, Tilmann; Ayoubi, Torik; Soreq, Hermona; Verhaagen, Joost; F. Swaab, Dick; Aerts, Stein; De Strooper, Bart

doi:10.1002/emmm.201201974

Public

Alteration of the microRNA network during the progression of Alzheimer's disease

Published in EMBO Molecular Medicine • Sep 9, 2013

Authors:

Pierre Lau

Koen Bossers

Rekin’s Janky

Abstract

An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late-onset AD (LOAD) patients and 23 controls, showing deregulation of 35 miRNAs. Profiling of miRNAs in the prefrontal cortex of a second independent cohort of 49 patients groupe...

Subject

microRNA

Downregulation and upregulation

Biology

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