The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo

B. Neufeld, Edward; E. Wastney, Meryl; C. Patel, Shutish; Suresh, Sundar; Cooney, Adele; K. Dwyer, Nancy; F. Roff, Calvin; Ohno, Kousaku; A. Morris, Jill; D. Carstea, Eugene; P. Incardona, John; F. Strauss, Jerome; T. Vanier, Marie; C. Patterson, Marc; O. Brady, Roscoe; G. Pentchev, Peter; Joan Blanchette‐Mackie, E.

doi:10.1074/jbc.274.14.9627

Public

The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo

Published in Journal of Biological Chemistry • Apr 1, 1999

Authors:

Edward B. Neufeld

Meryl E. Wastney

Shutish C. Patel

Abstract

Niemann-Pick C disease (NP-C) is a neurovisceral lysosomal storage disorder. A variety of studies have highlighted defective sterol trafficking from lysosomes in NP-C cells. However, the heterogeneous nature of additional accumulating metabolites suggests that the cellular lesion may involve a more ...

Subject

NPC1

Lysosome

Cell biology

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