Hind‐limb paraparesis in a rat model for neurolathyrism associated with apoptosis and an impaired vascular endothelial growth factor system in the spinal cord

Kusama‐Eguchi, Kuniko; Yamazaki, Yoshiko; Ueda, Tadashi; Suda, Atsuhiro; Hirayama, Yukari; Ikegami, Fumio; Watanabe, Kazuko; May, Mike; Lambein, Fernand; Kusama, Tadashi

doi:10.1002/cne.22257

Public

Hind‐limb paraparesis in a rat model for neurolathyrism associated with apoptosis and an impaired vascular endothelial growth factor system in the spinal cord

Published in The Journal of Comparative Neurology • Nov 20, 2009

Authors:

Kuniko Kusama‐Eguchi

Yoshiko Yamazaki

Tadashi Ueda

Abstract

Neurolathyrism is a motor neuron disease characterized by lower limb paraparesis. It is associated with ingestion of a plant excitotoxin, beta-N-oxalyl-L-alphabeta-diaminopropionic acid (L-beta-ODAP), an agonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate-type glutamat...

Subject

Spinal cord

Lumbar Spinal Cord

Biology

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