Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

Desmoulière, Alexis; Geinoz, Antoine; Gabbiani, F; Gabbiani, Giulio

doi:10.1083/jcb.122.1.103

Public

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

Published in The Journal of Cell Biology • Jul 1, 1993

Authors:

Alexis Desmoulière

Antoine Geinoz

F Gabbiani

Abstract

Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM) cells, including the presence of microfilament bundles and the expression of alpha-SM actin, the actin isoform typical of vascular SM cells. Myofibroblasts have been propose...

Subject

Myofibroblast

Biology

Granulation tissue

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