Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice.

Xie, Zhonglin; Lau, Kai; Eby, Bonnie; Lozano, Pedro; He, Chaoyong; Pennington, Becky; Li, Hongliang; Rathi, Shradha; Dong, Yunzhou; Tian, Rong; Kem, David; Zou, Ming-Hui

doi:10.2337/db10-0351

Public

Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice.

Shared by NobleBlocks on Jun 1, 2011 • 12:00 AM UTC

Authors:

Zhonglin Xie

Kai Lau

Bonnie Eby

Abstract

OBJECTIVE: Autophagy is a critical cellular system for removal of aggregated proteins and damaged organelles. Although dysregulated autophagy is implicated in the development of heart failure, the role of autophagy in the development of diabetic cardiomyopathy has not been studied. We investigated w...

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