MicroRNA‐146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins

Tang, Yuanjia; Luo, Xiaobing; Cui, Huijuan; Xu-ming, NI; Yuan, Min; Guo, Yanzhi; Huang, Xinfang; Zhou, Haibo; de Vries, Niek; P. Tak, Paul; Chen, Shun‐le; Shen, Nan

doi:10.1002/art.24436

Public

MicroRNA‐146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins

Published in Arthritis & Rheumatism • Mar 30, 2009

Authors:

Yuanjia Tang

Xiaobing Luo

Huijuan Cui

Abstract

OBJECTIVE: MicroRNA have recently been identified as regulators that modulate target gene expression and are involved in shaping the immune response. This study was undertaken to investigate the contribution of microRNA-146a (miR-146a), which was identified in the pilot expression profiling step, to...

Subject

microRNA

Peripheral blood mononuclear cell

Interferon

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