The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

Sancey, Lucie; Lux, François; M. Kotb, S.; Roux, Saartjie; Dufort, Sandrine; Bianchi, Alessandro; Crémillieux, Yannick; Fries, Peter; Coll, J-L; Rodriguez‐Lafrasse, Claire; Janier, M.; Dutreix, Marie; Barberi‐Heyob, Muriel; Boschetti, Fréderic; Denat, Franck; Louis, Cédric; Porcel, Erika; Lacombe, S.; Le Duc, Géraldine; Deutsch, Éric; Perfettini, J-L; Detappe, Alexandre; Verry, Camille; Berbeco, R.; T. Butterworth, Karl; J. McMahon, Stephen; M. Prise, Kevin; Perriat, Pascal; Tillement, Olivier

doi:10.1259/bjr.20140134

Public

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

Published in British Journal of Radiology • Jul 3, 2014

Authors:

Lucie Sancey

François Lux

S. M. Kotb

Abstract

A new efficient type of gadolinium-based theranostic agent (AGuIX®) has recently been developed for MRI-guided radiotherapy (RT). These new particles consist of a polysiloxane network surrounded by a number of gadolinium chelates, usually 10. Owing to their small size (<5 nm), AGuIX typically exhibi...

Subject

Radioresistance

Gadolinium

Radiation therapy

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