Retrospective Analysis of Topoisomerase IIa Amplifications and Deletions As Predictive Markers in Primary Breast Cancer Patients Randomly Assigned to Cyclophosphamide, Methotrexate, and Fluorouracil or Cyclophosphamide, Epirubicin, and Fluorouracil: Danish Breast Cancer Cooperative Group

Knoop, Ann; Knudsen, Helle; Balslev, Eva; Rasmussen, Birgitte; Overgaard, Jens; Vang Nielsen, Kirsten; Schönau, Andreas; Gunnarsdóttir, K.; Ege Olsen, Karen; T. Mouridsen, Henning; Ejlertsen, Bent

doi:10.1200/jco.2005.11.007

Public

Retrospective Analysis of Topoisomerase IIa Amplifications and Deletions As Predictive Markers in Primary Breast Cancer Patients Randomly Assigned to Cyclophosphamide, Methotrexate, and Fluorouracil or Cyclophosphamide, Epirubicin, and Fluorouracil: Danish Breast Cancer Cooperative Group

Published in Journal of Clinical Oncology • Oct 18, 2005

Authors:

Ann Knoop

Helle Knudsen

Eva Balslev

Abstract

PURPOSE: The aim of the study was to evaluate the predictive value of HER2 and topoisomerase IIalpha gene (TOP2A) for the efficacy of epirubicin in the adjuvant setting of breast cancer patients. PATIENTS AND METHODS: In the Danish Breast Cancer Cooperative Group trial 89D, 980 pre- and postmenopaus...

Subject

Epirubicin

Medicine

Fluorouracil

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