PPARγ Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Lefèvre, Lise; Galès, Amandine; Olagnier, David; Bernad, José; Perez, Laurence; Burcelin, Rémy; Valentin, Alexis; Auwerx, Johan; Pipy, Bernard; Coste, Agnès

doi:10.1371/journal.pone.0012828

Public

PPARγ Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Published in PLoS ONE • Sep 20, 2010

Authors:

Lise Lefèvre

Amandine Galès

David Olagnier

Abstract

Obesity is associated with a chronic low-grade inflammation that predisposes to insulin resistance and the development of type 2 diabetes. In this metabolic context, gastrointestinal (GI) candidiasis is common. We recently demonstrated that the PPARγ ligand rosiglitazone promotes the clearance of Ca...

Subject

Macrophage polarization

Rosiglitazone

Tumor necrosis factor alpha

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