<i>In Vivo</i> Measurement of Brain GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally Exposed to Manganese

Dydak, Ulrike; Jiang, Yue‐Ming; Long, Liling; Zhu, He; Chen, Jian; Li, Wen-Mei; A.E. Edden, Richard; Hu, Shuguang; Fu, Xue; Long, Zaiyang; Mo, Xue-An; Meier, D.; Harezlak, Jaroslaw; Aschner, Michael; B. Murdoch, James; Zheng, Wei

doi:10.1289/ehp.1002192

Public

In Vivo Measurement of Brain GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally Exposed to Manganese

Published in Environmental Health Perspectives • Sep 28, 2010

Authors:

Ulrike Dydak

Yue‐Ming Jiang

Liling Long

Abstract

BACKGROUND: Exposure to excessive levels of manganese (Mn) is known to induce psychiatric and motor disorders, including parkinsonian symptoms. Therefore, finding a reliable means for early detection of Mn neurotoxicity is desirable. OBJECTIVES: Our goal was to determine whether in vivo brain levels...

Subject

Globus pallidus

Thalamus

Putamen

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