MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

T. Humphreys, David; J. Westman, Belinda; I. K. Martin, David; Preiß, Thomas

doi:10.1073/pnas.0506482102

Public

MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

Published in Proceedings of the National Academy of Sciences • Nov 15, 2005

Authors:

David T. Humphreys

Belinda J. Westman

David I. K. Martin

Abstract

MicroRNAs (miRNAs) repress translation of target mRNAs by interaction with partially mismatched sequences in their 3' UTR. The mechanism by which they act on translation has remained largely obscure. We examined the translation of mRNAs containing four partially mismatched miRNA-binding sites in the...

Subject

Internal ribosome entry site

Eukaryotic initiation factor

Translation (biology)

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