FGFR3 and P53 Characterize Alternative Genetic Pathways in the Pathogenesis of Urothelial Cell Carcinoma

W.G. van Rhijn, Bas; van der Kwast, Theodorus; N. Vis, André; J. Kirkels, Wim; R. Boevé, Egbert; C. Jöbsis, Adriaan; C. Zwarthoff, Ellen

doi:10.1158/0008-5472.can-03-2421

Public

FGFR3 and P53 Characterize Alternative Genetic Pathways in the Pathogenesis of Urothelial Cell Carcinoma

Published in Cancer Research • Mar 15, 2004

Authors:

Bas W.G. van Rhijn

Theodorus van der Kwast

André N. Vis

Abstract

Fibroblast growth factor receptor 3 (FGFR3) and P53 mutations are frequently observed in bladder cancer. We here describe the distribution of FGFR3 mutations and P53 overexpression in 260 primary urothelial cell carcinomas. FGFR3 mutations were observed in 59% and P53 overexpression in 25%. Interest...

Subject

Pathogenesis

Cancer research

Fibroblast growth factor receptor 3

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