Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

Jones, Graeme; Sebba, Anthony; Gu, Jianhui; B. Lowenstein, Mitchell; Calvo, Andrea; J. Gómez‐Reino, Juan; Siri, Daniel; Tomšič, Matija; Alecock, Emma; Woodworth, Thasia; C. Genovese, M.

doi:10.1136/ard.2008.105197

Public

Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

Published in Annals of the Rheumatic Diseases • Mar 19, 2009

Authors:

Graeme Jones

Anthony Sebba

Jianhui Gu

Abstract

BACKGROUND: The anti-interleukin (IL) 6 receptor antibody tocilizumab inhibits signalling of IL6, a key cytokine in rheumatoid arthritis (RA) pathogenesis. OBJECTIVE: To evaluate through the AMBITION study the efficacy and safety of tocilizumab monotherapy versus methotrexate in patients with active...

Subject

Tocilizumab

Medicine

Rheumatoid arthritis

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