Extracellular Matrix Metalloproteinase Inducer (CD147) Confers Resistance of Breast Cancer Cells to Anoikis through Inhibition of Bim

Yang, Jinming; O’Neill, Peter; Jin, Wei; A. Foty, Ramsey; Medina, Daniel; Xu, Zu‐De; Lomas, Mehnaaz; M. Arndt, Greg; Tang, Yi; T. Nakada, Marian; Li, Yan; N. Hait, William

doi:10.1074/jbc.m508421200

Public

Extracellular Matrix Metalloproteinase Inducer (CD147) Confers Resistance of Breast Cancer Cells to Anoikis through Inhibition of Bim

Published in Journal of Biological Chemistry • Jan 28, 2006

Authors:

Jinming Yang

Peter O’Neill

Wei Jin

Abstract

Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, promotes invasion, metastasis, and growth and survival of malignant cells and confers resistance to some chemotherapeu...

Subject

Anoikis

Small interfering RNA

Chemistry

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