Immune surveillance in multiple sclerosis patients treated with natalizumab

Stüve, Olaf; M. Marra, Christina; R. Jerome, Keith; Cook, Linda; D. Cravens, Petra; Cepok, Sabine; M. Frohman, Elliot; Theodore Phillips, J.; Arendt, Gabriele; Hemmer, Bernhard; Monson, Nancy; K. Racke, Michael

doi:10.1002/ana.20858

Public

Immune surveillance in multiple sclerosis patients treated with natalizumab

Published in Annals of Neurology • Apr 21, 2006

Authors:

Olaf Stüve

Christina M. Marra

Keith R. Jerome

Abstract

OBJECTIVE: Our objective was to test whether natalizumab, an antibody against very late activating antigen (VLA)-4, interferes with central nervous system immune surveillance as assessed by leukocyte cell numbers and cellular phenotypes in cerebrospinal fluid (CSF) and peripheral blood. METHODS: Cel...

Subject

Natalizumab

Multiple sclerosis

Medicine

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