NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death BothIn VitroandIn Vivo

Liu, Yitao; Pan Wong, Tak; Aarts, Michelle; Rooyakkers, Amanda; Liu, Lidong; Weita Lai, Ted; Wu, Dong; Lu, Jie; Tymianski, Michael; Marie Craig, Ann; Tian Wang, Yu

doi:10.1523/jneurosci.0116-07.2007

Public

NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death BothIn VitroandIn Vivo

Published in Journal of Neuroscience • Mar 14, 2007

Authors:

Yitao Liu

Tak Pan Wong

Michelle Aarts

Abstract

Well-documented experimental evidence from both in vitro and in vivo models of stroke strongly supports the critical involvement of NMDA receptor-mediated excitotoxicity in neuronal damage after stroke. Despite this, the results of clinical trials testing NMDA receptor antagonists as neuroprotectant...

Subject

Excitotoxicity

NMDA receptor

Neuroprotection

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