A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome

Sultan, Marc; H. Schulz, Marcel; Richard, Hugues; Magen, Alon; Klingenhoff, Andreas; Scherf, Matthias; Seifert, Martin; Borodina, Tatiana; V. Soldatov, Aleksey; Parkhomchuk, Dmitri; Schmidt, Dominic; O’Keeffe, Sean; A. Haas, Stefan; Vingron, Martin; Lehrach, Hans; Yaspo, Marie‐Laure

doi:10.1126/science.1160342

Public

A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome

Published in Science • Jul 3, 2008

Authors:

Marc Sultan

Marcel H. Schulz

Hugues Richard

Abstract

The functional complexity of the human transcriptome is not yet fully elucidated. We report a high-throughput sequence of the human transcriptome from a human embryonic kidney and a B cell line. We used shotgun sequencing of transcripts to generate randomly distributed reads. Of these, 50% mapped to...

Subject

Transcriptome

Biology

Polyadenylation

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